Bruton's tyrosine kinase (BTK) is an essential component of multiple signaling pathways that
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …

Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …

Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19–infected patients
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Inflammasome activation has been implicated in various inflammatory diseases including
post-ischaemic inflammation after stroke. Inflammasomes mediate activation of caspase-1 …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell
receptor signaling in the development and functioning of adaptive immunity. Growing …

The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

One of the mechanisms by which the innate immune system senses the invasion of
pathogenic microorganisms is through the Toll-like receptors (TLRs), which recognize …