Oxygen (O 2) toxicity remains a concern, particularly to the lung. This is mainly related to
excessive production of reactive oxygen species (ROS). Supplemental O 2, ie inspiratory O …

Acute respiratory failure (ARF) is defined by acute and progressive hypoxemia caused by
various cardiorespiratory or systemic diseases in previously healthy patients. Among ARF …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Rationale: Supplemental oxygen is widely administered to ICU patients, but appropriate
oxygenation targets remain unclear. Objectives: This study aimed to determine whether a …

Importance Among critically ill adults, randomized trials have not found oxygenation targets
to affect outcomes overall. Whether the effects of oxygenation targets differ based on an …

Purpose The effect of high arterial oxygen levels and supplemental oxygen administration
on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI …

Importance Oxygen supplementation is a cornerstone treatment in pediatric critical care.
Accumulating evidence suggests that overzealous use of oxygen, leading to hyperoxia, is …

Importance The incidence of hypertriglyceridemia–associated acute pancreatitis (HTG-AP)
is increasing. Plasmapheresis is theoretically effective in removing triglyceride from plasma …

Background Hyperoxemia may aggravate reperfusion brain injury after cardiac arrest. The
aim of this study was to study the associations between different levels of hyperoxemia in the …

Background The mainstay treatment for hypoxaemia is oxygen therapy, which is given to the
vast majority of adults admitted to the intensive care unit (ICU). The practice of oxygen …