An overview on the anticancer activity of Ru (II)/acylthiourea complexes

GH Ribeiro, AR Costa, AR de Souza… - Coordination Chemistry …, 2023 - Elsevier
This review outlines research on the development of ruthenium complexes containing
acylthiourea ligands with potential antitumor activity, which have been leveraged in recent …

Medicinal importance, coordination chemistry with selected metals (Cu, Ag, Au) and chemosensing of thiourea derivatives. A review

E Khan, S Khan, Z Gul… - Critical Reviews in …, 2021 - Taylor & Francis
Thiourea and its derivatives are versatile compounds used in several fields of life ranging
from medicinal to chemosensor applications. In this review article, generally used …

Current developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas: advances Continue…

A Saeed, MN Mustafa, M Zain-ul-Abideen… - Journal of Sulfur …, 2019 - Taylor & Francis
(acyl/aroyl)-3-(substituted) thioureas are exciting structures in the fields of organic synthesis,
material sciences, and biomedical research. Of particular significance is the fact that acyl …

Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical …

FA Larik, A Saeed, PA Channar, U Muqadar… - European Journal of …, 2017 - Elsevier
A series of novel 1-pentanoyl-3-arylthioureas was designed as new mushroom tyrosinase
inhibitors and free radical scavengers. The title compounds were obtained in excellent yield …

New acetylphenol-based acyl thioureas broaden the scope of drug candidates for urease inhibition: synthesis, in vitro screening and in silico analysis

U Zahra, S Zaib, A Saeed, M ur Rehman… - International Journal of …, 2022 - Elsevier
Helicobacter pylori urease remains a validated drug target for the eradication of pervasive
chronic stomach infection that leads to severe human health diseases such as gastritis and …

Synthesis, molecular docking studies of coumarinyl-pyrazolinyl substituted thiazoles as non-competitive inhibitors of mushroom tyrosinase

A Saeed, PA Mahesar, PA Channar, Q Abbas… - Bioorganic …, 2017 - Elsevier
A series of coumarinyl-pyrazolinyl substituted thiazoles derivatives were synthesized and
their inhibitory effects on the DPPH and mushroom tyrosinase were evaluated. The results …

Novel C-2 symmetric molecules as α-glucosidase and α-amylase inhibitors: design, synthesis, kinetic evaluation, molecular docking and pharmacokinetics

D Shahzad, A Saeed, FA Larik, PA Channar, Q Abbas… - Molecules, 2019 - mdpi.com
A series of symmetrical salicylaldehyde-bishydrazine azo molecules, 5a–5h, have been
synthesized, characterized by 1H-NMR and 13C-NMR, and evaluated for their in vitro α …

Sulfonamide-linked ciprofloxacin, sulfadiazine and amantadine derivatives as a novel class of inhibitors of jack bean urease; synthesis, kinetic mechanism and …

PA Channar, A Saeed, F Albericio, FA Larik, Q Abbas… - Molecules, 2017 - mdpi.com
Sulfonamide derivatives serve as an important building blocks in the drug design discovery
and development (4D) process. Ciprofloxacin-, sulfadiazine-and amantadine-based …

Hybrid pharmacophoric approach in the design and synthesis of coumarin linked pyrazolinyl as urease inhibitors, kinetic mechanism and molecular docking

A Saeed, PA Mahesar, PA Channar… - Chemistry & …, 2017 - Wiley Online Library
The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide
derivatives and their biological activity as inhibitors of jack bean urease. The coumarinyl …

Green Synthesis of Gold and Iron Nanoparticles for Targeted Delivery: An In Vitro and In Vivo Study

B Khanzada, N Akthar, MZ Bhatti, H Ismail… - Journal of …, 2021 - Wiley Online Library
Nanotechnology has vast applications in almost all fields of science and technology. The
use of medicinal plants for the synthesis of metallic nanoparticles has gained much attention …