Nonessential amino acids are synthesized de novo and therefore not diet dependent. In
contrast, essential amino acids must be obtained through nutrition since they cannot be …

Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb),
which affects approximately a million people worldwide. It is characterized by a single …

Sickle cell disease and its variants constitute the most common inherited blood disorders
affecting millions of individuals worldwide. Significant information regarding the nature of the …

β-thalassemia and sickle cell disease (SCD) are inherited hemoglobinopathies that result in
both quantitative and qualitative variations in the β-globin chain. These in turn lead to …

Disclosure Statement: There are no conflicts of interest relevant to this review article.
Claudia R. Morris, MD is the inventor or co-inventor of several Children's Hospital & …

Many studies report estimated pulmonary artery systolic pressure (ePASP) in patients with
sickle cell disease (SCD) screened by echocardiography. To better understand the …

Sickle cell disease (SCD) is the most severe monogenic hemoglobinopathy caused by a
single genetic mutation that leads to repeated polymerization and depolymerization of …

Therapeutic approaches in pediatric pulmonary arterial hypertension (PAH) are based
primarily on clinician experience, in contrast to the evidence-based approach in adults with …

The management of sickle cell nephropathy (SCN) at an early stage is an important issue to
prevent renal and cardiovascular morbidity and mortality. This study aimed to evaluate in …

This study investigated the clinical value of plasma asymmetrical dimethyl-l-arginine (ADMA)
level in the diagnosis, staging, and treatment response in congenital heart disease (CHD) …