ABSTRACT On December 17, 2018, the North American branch of the International Life
Sciences Institute (ILSI North America) convened a workshop “Can We Begin to Define a …

Risk of disease is multifactorial and can be shaped by socio-economic, demographic,
cultural, environmental and genetic factors. Our understanding of the genetic determinants …

The aim of this updated guideline is to provide comprehensive and timely evidence-based
recommendations on the prevention of future stroke among survivors of ischemic stroke or …

Importance Uncertainty remains about the efficacy of folic acid therapy for the primary
prevention of stroke because of limited and inconsistent data. Objective To test the primary …

Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …

Background Whether a modestly elevated homocysteine level is causally associated with an
increased risk of cardiovascular disease remains unestablished. We conducted a Mendelian …

Hyperhomocysteinemia is recognized as a risk factor for several diseases, including
cardiovascular and neurological conditions. Homocysteine (HCys) is a key metabolite …

Background Results from observational and genetic epidemiological studies suggest that
lower serum homocysteine levels are associated with lower incidence of cardiovascular …

Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …