Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …

Highlights•Parvalbumin (PV) cell alterations contribute to cognitive deficits in
schizophrenia.•PV cells have multiple gene expression disturbances that impair their …

Parvalbumin-positive (PV+) neurons control the timing of pyramidal cell output in cortical
neuron networks. In the prefrontal cortex (PFC), PV+ neuron activity is involved in cognitive …

Objective In schizophrenia, alterations within the prefrontal cortical GABA system appear to
be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin …

Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD),
identification of convergent pathways and/or common molecular endpoints in the …

Autism spectrum disorders (ASD) comprise a number of heterogeneous
neurodevelopmental diseases characterized by core behavioral symptoms in the domains of …

Cognitive dysfunction is a disabling and core feature of schizophrenia. Cognitive
impairments have been linked to disturbances in inhibitory (gamma-aminobutyric acid …

Schizophrenia is a complex brain disorder associated with deficits in synaptic connectivity.
The insidious onset of this illness during late adolescence and early adulthood has been …

Members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9,
collectively identified as electrically silent voltage-gated K+ channel [KvS] subunits) do not …