Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant
production of autoreactive immune cells and/or autoantibodies against healthy cells and …

CD8+ T cells are classically recognized as adaptive lymphocytes based on their ability to
recognize specific foreign antigens and mount memory responses. However, recent studies …

Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following
infection, naive T cells differentiate into various subsets of effector and memory T cells …

The early life immune system is characterized by unique developmental milestones.
Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a …

MicroRNAs and tRFs are classes of small non-coding RNAs, known for their roles in
translational regulation of genes. Advances in next-generation sequencing (NGS) have …

During the ontogeny of the mammalian immune system, distinct lineages of cells arise from
fetal and adult hematopoietic stem cells (HSCs) during specific stages of development …

Historically, the immune system was believed to develop along a linear axis of maturity from
fetal life to adulthood. Now, it is clear that distinct layers of immune cells are generated from …

Epigenetic regulation of transcription is a collective term that refers to mechanisms known to
regulate gene transcription without changing the underlying DNA sequence. These …

Cellular programming of naïve T cells can improve the efficacy of adoptive T-cell therapy.
However, the current ex vivo engineering of T cells requires the pre-activation of T cells …