The NF-κB family of transcription factors regulates the induction and resolution of
inflammation. Two main pathways, classical and alternative, control the nuclear …

HIV is a highly adaptive, rapidly evolving virus, which is associated with renal diseases
including collapsing glomerulopathy—the classic histomorphological form of HIV-associated …

NF-κB-mediated inflammation is the major pathology in chronic kidney diseases, including
HIV-associated nephropathy (HIVAN) that ultimately progresses to end stage renal disease …

Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of
reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis …

Collapsing glomerulopathy (CG) has become an important cause of ESRD. First delineated
from other proteinuric glomerular lesions in the 1980s, CG is now recognized as a common …

The activation of the poly (ADP-ribose) polymerase (PARP) plays an important role in the
pathophysiology of various diseases associated with oxidative stress. We found increased …

Podocyte injury resulting from a loss of differentiation is the hallmark of many glomerular
diseases. We previously showed that retinoic acid (RA) induces podocyte differentiation via …

Maintenance of mitochondrial structure and function is critical for preventing podocyte
apoptosis and eventual glomerulosclerosis in the kidney; however, the transcription factors …

Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF)
and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting …

Glycinin is a major anti-nutritional factor of soybean. Glycinin inhibits growth and impairs
intestinal health in grass carp and Jian carp, but the underlying mechanisms are largely …