Therapeutic application of nucleic acids requires their encapsulation in nanosized carriers
that enable safe and efficient intracellular delivery. Before the desired site of action is …

Abstract Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus
and botulism, respectively, are the most potent toxic molecules known to mankind. This …

Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here
we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan …

Pain is one of the most significant causes of suffering and disability world-wide, and
arguably the most burdensome global health challenge. The growing number of patients …

Polycations that are degradable by reduction of disulfide bonds are developed for
applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of …

Spinal cord injury triggers a complex set of events that lead to tissue healing without the
restoration of normal function due to the poor regenerative capacity of the spinal cord …

Several hereditary cancer syndromes are associated with nonsense mutations that create
premature termination codons (PTC). Therapeutic strategies involving readthrough induction …

Much attention has been directed toward improving nonviral gene delivery in order to
replace viral vectors and overcome the barriers to clinical gene therapy. Specifically …

Protein and peptide toxins offer an invaluable source for the development of actively
targeted drug delivery systems. They avidly bind to a variety of cognate receptors, some of …

When Clostridium tetani was discovered and identified as a Gram-positive anaerobic
bacterium of the genus Clostridium, the possibility of turning its toxin into a valuable …