Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the
generation/function of bone forming and resorbing cells. Aging also decreases connexin43 …

Gap junctions and connexin hemichannels mediate intercellular and extracellular
communication, respectively. While gap junctions are seen as the “good guys” by controlling …

Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of
the most common sites of metastasis for many solid tumors. Once cancer cells colonize in …

Oxidative stress is a major risk factor that causes osteocyte cell death and bone loss. Prior
studies primarily focus on the function of cell surface expressed Cx43 channels. Here, we …

Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low
bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically …