Ferritin-based nanomedicine for disease treatment
Y Zhu, Y Zhu, T Cao, X Liu, X Liu, Y Yan, Y Shi… - Medical …, 2023 - degruyter.com
Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly
uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity …
uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity …
An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies
Despite decades of antibody research, it remains challenging to predict the specificity of an
antibody solely based on its sequence. Two major obstacles are the lack of appropriate …
antibody solely based on its sequence. Two major obstacles are the lack of appropriate …
Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice
Seasonal influenza virus vaccines are effective when they are well matched to circulating
strains. Because of antigenic drift/change in the immunodominant hemagglutinin (HA) head …
strains. Because of antigenic drift/change in the immunodominant hemagglutinin (HA) head …
Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 subunit vaccine combination prevents morbidity in mice
E Karaaslan, TE Sorvillo, FEM Scholte, TJ O'Neal… - npj Vaccines, 2024 - nature.com
Abstract Immunizing mice with Crimean-Congo hemorrhagic fever virus (CCHFV)
nucleoprotein (NP), glycoprotein precursor (GPC), or with the GP38 domain of GPC, can be …
nucleoprotein (NP), glycoprotein precursor (GPC), or with the GP38 domain of GPC, can be …
[HTML][HTML] Multifaceted virus-like particles: Navigating towards broadly effective influenza A virus vaccines
JAM Norizwan, WS Tan - Current Research in Microbial Sciences, 2024 - Elsevier
The threat of influenza A virus (IAV) remains an annual health concern, as almost 500,000
people die each year due to the seasonal flu. Current flu vaccines are highly dependent on …
people die each year due to the seasonal flu. Current flu vaccines are highly dependent on …
A novel “prime and pull” strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against …
Z Wang, Y He, W Wang, Y Tian, C Ge, F Jia… - Journal of …, 2023 - Springer
Vaccination is still the most promising strategy for combating influenza virus pandemics.
However, the highly variable characteristics of influenza virus make it difficult to develop …
However, the highly variable characteristics of influenza virus make it difficult to develop …
Generation and characterization of a nanobody against the avian influenza virus H7 subtype
X Huang, W Li, X Cao, Q Zhang, Y Lin, S Xu… - International Journal of …, 2024 - Elsevier
Avian influenza virus (AIV) H7N9 diseases have been recently reported, raising concerns
about a potential pandemic. Thus, there is an urgent need for effective therapeutics for AIV …
about a potential pandemic. Thus, there is an urgent need for effective therapeutics for AIV …
[HTML][HTML] An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies
Despite decades of antibody research, it remains challenging to predict the specificity of an
antibody solely based on its sequence. Two major obstacles are the lack of appropriate …
antibody solely based on its sequence. Two major obstacles are the lack of appropriate …
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses
Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza
A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer …
A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer …
A vaccine platform targeting lung-resident memory CD4+ T-cells provides protection against heterosubtypic influenza infections in mice and ferrets
KH Ko, HS Bae, JW Park, JS Lee, S Park, J Heo… - Nature …, 2024 - nature.com
Lung tissue-resident memory T (TRM) cells induced by influenza vaccination are crucial for
heterosubtypic immunity upon re-exposure to the influenza virus, enabling rapid and robust …
heterosubtypic immunity upon re-exposure to the influenza virus, enabling rapid and robust …