Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent

MM Bayliak, VI Lushchak - Ageing research reviews, 2021 - Elsevier
An intermediate of tricarboxylic acid cycle alpha-ketoglutarate (AKG) is involved in
pleiotropic metabolic and regulatory pathways in the cell, including energy production …

Fructose-mediated AGE-RAGE axis: approaches for mild modulation

H Semchyshyn - Frontiers in Nutrition, 2024 - frontiersin.org
Fructose is a valuable and healthy nutrient when consumed at normal levels (≤ 50 g/day).
However, long-term consumption of excessive fructose and elevated endogenous …

[HTML][HTML] Neuroprotective potential of hydroethanolic hull extract of Juglans regia L. on isoprenaline induced oxidative damage in brain of Wistar rats

P Sharma, PK Verma, S Sood, NK Pankaj, S Agarwal… - Toxicology Reports, 2021 - Elsevier
The study was aimed at assessing isoprenaline (ISO) induced oxidative damage in brain of
Wistar rats and its protection by hydroethanolic hull extract of Juglans regia. Administration …

Effects of exercise training on behavior and brain function after high dose isoproterenol-induced cardiac damage

K Tóth, T Oroszi, EA van der Zee, C Nyakas… - Scientific Reports, 2021 - nature.com
Acute sympathetic stress can result in cardiac fibrosis, but may also lead to mental
dysfunction. Exercise training after isoproterenol (ISO)-induced acute sympathetic stress …

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

A Faulkner, A Tamiato, W Cathery, A Rampin… - Diabetologia, 2020 - Springer
Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We
reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes …

Whole-body vibration as a passive alternative to exercise after myocardial damage in middle-aged female rats: Effects on the heart, the brain, and behavior

K Tóth, T Oroszi, C Nyakas, EA van der Zee… - Frontiers in Aging …, 2023 - frontiersin.org
Background Females with cardiovascular disease seem more vulnerable to develop
concomitant mental problems, such as depression and cognitive decline. Although exercise …

Protective effects of alpha-ketoglutarate against aluminum toxicity in Drosophila melanogaster

MM Bayliak, MP Lylyk, DV Gospodaryov… - … and Physiology Part C …, 2019 - Elsevier
In recent years, Drosophila melanogaster has emerged as a model for studies on aluminum
toxicity. The current study aimed to disclose the mechanisms of aluminum toxicity in D …

[HTML][HTML] In Silico and In Vivo Studies of β-Sitosterol Nanoparticles as a Potential Therapy for Isoprenaline-Induced Cognitive Impairment in Myocardial Infarction …

PS Tallapalli, YD Reddy, DA Yaraguppi, SP Matangi… - Pharmaceuticals, 2024 - mdpi.com
Objective: This study aimed to compare the effects of β-sitosterol nanoparticles (BETNs) and
β-sitosterol (BET) on cognitive impairment, oxidative stress, and inflammation in a …

Cardioprotective effect of hemin in isoprenaline‐induced myocardial infarction: role of ATP‐sensitive potassium channel and endothelial nitric oxide synthase

MMM Refaie, RA Rifaai, AMA Bayoumi… - Fundamental & …, 2020 - Wiley Online Library
Ischemic heart disease is a common cardiac health problem. Despite the significant
advances in prevention and treatment of this disorder, its incidences and complications are …

Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus

NI Shehata, MA Abdelsamad, HAA Amin… - Journal of Food …, 2022 - Wiley Online Library
This study aimed to evaluate the potential neuroprotective effects of ketogenic diet (KD)
against the neuronal disruptions induced by SE in lithium‐pilocarpine rat model of status …