The current state of peptide drug discovery: back to the future?

A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate

U Anand, A Bandyopadhyay, NK Jha… - Biofactors, 2023 - Wiley Online Library
In the last two decades, protein–protein interactions (PPIs) have been used as the main
target for drug development. However, with larger or superficial binding sites, it has been …

Phage display as a promising approach for vaccine development

L Aghebati-Maleki, B Bakhshinejad… - Journal of biomedical …, 2016 - Springer
Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted
growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine …

[图书][B] Practical handbook of microbiology

LH Green, E Goldman - 2021 - books.google.com
Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

Evolution of phage display libraries for therapeutic antibody discovery

Y Zhang - MAbs, 2023 - Taylor & Francis
Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most
important classes of biotherapeutics in recent decades. The success of mAb is due to their …

Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage

M Sojitra, S Sarkar, J Maghera, E Rodrigues… - Nature chemical …, 2021 - nature.com
The central dogma of biology does not allow for the study of glycans using DNA sequencing.
We report a liquid glycan array (LiGA) platform comprising a library of DNA 'barcoded'M13 …

Peptide-based strategies for targeted tumor treatment and imaging

A Ayo, P Laakkonen - Pharmaceutics, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide. The development of cancer-specific
diagnostic agents and anticancer toxins would improve patient survival. The current and …

High-throughput sequencing enhanced phage display enables the identification of patient-specific epitope motifs in serum

A Christiansen, JV Kringelum, CS Hansen, KL Bøgh… - Scientific reports, 2015 - nature.com
Phage display is a prominent screening technique with a multitude of applications including
therapeutic antibody development and mapping of antigen epitopes. In this study, phages …

Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides

I Rentero Rebollo, M Sabisz, V Baeriswyl… - Nucleic acids …, 2014 - academic.oup.com
High-throughput sequencing was previously applied to phage-selected peptides in order to
gain insight into the abundance and diversity of isolated peptides. Herein we developed a …

Lead discovery and optimization strategies for peptide macrocycles

A Bhat, LR Roberts, JJ Dwyer - European journal of medicinal chemistry, 2015 - Elsevier
Peptide macrocycles represent a chemical space where the best of biological tools can
synergize with the best of chemical approaches in the quest for leads against undruggable …