The structural biology of galectin-ligand recognition: current advances in modeling tools, protein engineering, and inhibitor design
CP Modenutti, JIB Capurro, S Di Lella… - Frontiers in Chemistry, 2019 - frontiersin.org
Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that
typically bind β-galactoside carbohydrates with high specificity. They are present in many …
typically bind β-galactoside carbohydrates with high specificity. They are present in many …
Medawar's PostEra: galectins emerged as key players during fetal-maternal glycoimmune adaptation
E Menkhorst, NG Than, U Jeschke… - Frontiers in …, 2021 - frontiersin.org
Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many
processes required for a successful pregnancy. Over the past decades, increasing evidence …
processes required for a successful pregnancy. Over the past decades, increasing evidence …
Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity
Y Si, Y Yao, GJ Ayala, X Li, Q Han, W Zhang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background The structure of human galectin-16 (Gal-16) has yet to be solved, and its
function has remained elusive. Methods X-ray crystallography was used to determine the …
function has remained elusive. Methods X-ray crystallography was used to determine the …
Structure–function studies of galectin‐14, an important effector molecule in embryology
Y Si, Y Li, T Yang, X Li, GJ Ayala, KH Mayo… - The FEBS …, 2021 - Wiley Online Library
The expression of prototype galectin‐14 (Gal‐14) in human placenta is higher than any
other galectin, suggesting that it may play a role in fetal development and regulation of …
other galectin, suggesting that it may play a role in fetal development and regulation of …
Modulation of the Gal-9/TIM-3 immune checkpoint with α-lactose. Does anomery of lactose matter?
Simple Summary The disaccharide lactose is a common excipient in pharmaceutical
products. In addition, the two anomers α-and β-lactose can exert immuno-modulatory effects …
products. In addition, the two anomers α-and β-lactose can exert immuno-modulatory effects …
Comparative study on the structures of intra-and extra-cellular polysaccharides from Penicillium oxalicum and their inhibitory effects on galectins
S Zhang, Z Qiao, Z Zhao, J Guo, K Lu, KH Mayo… - International Journal of …, 2021 - Elsevier
Here, we compare the content and composition of polysaccharides derived from the
mycelium (40.4 kDa intracellular polysaccharide, IPS) and culture (27.2 kDa extracellular …
mycelium (40.4 kDa intracellular polysaccharide, IPS) and culture (27.2 kDa extracellular …
Placental galectins: a subfamily of galectins lose the ability to bind β-galactosides with new structural features
X Pei, J Zhu, Y Wang, F Zhang, Y He… - Biology of …, 2023 - academic.oup.com
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins.
There are 16 different of galectins, each with a specific function determined by its distinct …
There are 16 different of galectins, each with a specific function determined by its distinct …
[HTML][HTML] Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma: Effects of glutathione on …
H Na, H Sayed, GJ Ayala, X Wang, Y Liu… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
Abstract Charcot-Leyden crystals (CLCs) are the hallmark of many eosinophilic-based
diseases, such as asthma. Here, we report that reduced glutathione (GSH) disrupts CLCs …
diseases, such as asthma. Here, we report that reduced glutathione (GSH) disrupts CLCs …
Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution
T Yang, Y Yao, X Wang, Y Li, Y Si, X Li, GJ Ayala… - …, 2020 - academic.oup.com
Abstract Galectin-13 (Gal-13) plays numerous roles in regulating the relationship between
maternal and fetal tissues. Low expression levels or mutations of the lectin can result in pre …
maternal and fetal tissues. Low expression levels or mutations of the lectin can result in pre …
Actin binding to galectin-13/placental protein-13 occurs independently of the galectin canonical ligand-binding site
X Li, Y Yao, T Liu, K Gu, Q Han, W Zhang… - …, 2021 - academic.oup.com
The gene for galectin-13 (Gal-13, placental protein 13) is only present in primates, and its
low expression level in maternal serum may promote preeclampsia. In the present study, we …
low expression level in maternal serum may promote preeclampsia. In the present study, we …