Highlights•Safety and potency of simian adenovirus vectors is now well established, most
recently in infants.•Viral vectored vaccines are effective against malaria and Ebola in field …

Ever since the discovery of vaccines, many deadly diseases have been contained
worldwide, ultimately culminating in the eradication of smallpox and polio, which …

Influenza virus causes acute upper and lower respiratory infections and is the most likely,
among known pathogens, to cause a large epidemic in humans. Influenza virus mutates …

Tissue-resident memory T cells (T RM) in the lungs are pivotal for protection against
repeated infection with respiratory viruses. However, the gradual loss of these cells over …

The severity of the 2017–18 influenza season, combined with the low efficacy for some
vaccine components, highlights the need to improve our current seasonal influenza vaccine …

Respiratory syncytial virus (RSV) causes respiratory infection in annual epidemics, with
infants and the elderly at particular risk of developing severe disease and death. However …

Introduction: Annual vaccination is one of the most efficient and cost-effective strategies to
prevent and control influenza epidemics. Most of the currently available influenza vaccines …

Introduction Respiratory syncytial virus (RSV) infection causes respiratory disease
throughout life, with infants and the elderly at risk of severe disease and death. RSV001 is a …

Lung tissue-resident memory T cells are crucial mediators of cellular immunity against
respiratory viruses; however, their gradual decline hinders the development of T cell–based …

Since the development of the first vaccine against smallpox over two centuries ago,
vaccination strategies have been at the forefront of significantly impacting the incidences of …