The rate at which cells enter the T cell pathway depends not only on the immigration of
hematopoietic precursors into the strong Notch signaling environment of the thymus but also …

T cells develop from multipotent progenitors by a gradual process dependent on intrathymic
Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell …

T‐cell differentiation is a tightly regulated developmental program governed by interactions
between transcription factors (TFs) and chromatin landscapes and affected by signals …

Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how
antigen recognition activates appropriate effector responses through nonspecific signaling …

While biomarkers have been shown to enhance the prognosis of patients with colorectal
cancer (CRC) compared to conventional treatments, there is a pressing need to discover …

T-cell development provides an excellent model system for studying lineage commitment
from a multipotent progenitor. The intrathymic development process has been thoroughly …

Understanding the mechanisms underlying diapause formation is crucial for gaining insight
into adaptive survival strategies across various species. In this study, we aimed to uncover …

How multipotent progenitors give rise to multiple cell types in defined numbers is a central
question in developmental biology. Epigenetic switches, acting at single gene loci, can …

Lymphocytes play a critical role in adaptive immunity and defense mechanisms, but the
molecular mechanisms by which hematopoietic stem and progenitor cells differentiate into T …

T-cell development provides an excellent model system for studying lineage commitment
from a multipotent progenitor. The intrathymic development process has been thoroughly …