The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic
steatosis) contribute to approximately 2.5 million deaths annually and are among the most …

The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …

Protein ser/thr phosphatase 2A family members (PP2A, PP4, and PP6) are implicated in the
control of numerous biological processes, but our understanding of the in vivo function and …

Hedgehog (Hh) signaling in vertebrates depends on intraflagellar transport (IFT) within
primary cilia. The Hh receptor Patched is found in cilia in the absence of Hh and is replaced …

Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue
homeostasis, and its deregulation leads to numerous human disorders including cancer …

The seven transmembrane protein Smoothened (Smo) is a critical component of the
Hedgehog (Hh) signaling pathway and is regulated by phosphorylation, dimerization, and …

Wnt signaling plays important roles in development and tumorigenesis. A central question
about the Wnt pathway is the regulation of β-catenin. Phosphorylation of β-catenin by CK1α …

A central question in Wnt signaling is the regulation of β-catenin phosphorylation and
degradation. Multiple kinases, including CKIα and GSK3, are involved in β-catenin …