Improving stem cell mobilization strategies: future directions

W Bensinger, JF DiPersio, JM McCarty - Bone marrow transplantation, 2009 - nature.com
Autologous hematopoietic SCT (auto-HSCT) provides hematopoietic support after high-dose
chemotherapy and is the standard of care for patients with multiple myeloma (MM) or …

Mobilization of hematopoietic stem cells

S Fu, J Liesveld - Blood reviews, 2000 - Elsevier
Hematopoietic stem cell transplantation has been extensively exploited as a therapeutic and
research modality and has revolutionized current patient care. At present, more and more …

Diffusion Limits of an in Vitro Thick Prevascularized Tissue

CK Griffith, C Miller, RCA Sainson, JW Calvert… - Tissue …, 2005 - liebertpub.com
Although tissue engineering promises to replace or restore lost function to nearly every
tissue in the body, successful applications are currently limited to tissue less than 2 mm in …

High CD34+ Cell Counts Decrease Hematologic Toxicity of Autologous Peripheral Blood Progenitor Cell Transplantation

N Ketterer, G Salles, M Raba… - Blood, The Journal …, 1998 - ashpublications.org
Optimal numbers of CD34+ cells to be reinfused in patients undergoing peripheral blood
progenitor cell (PBPC) transplantation after high-dose chemotherapy are still unknown …

Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with …

MJ Dugan, RT Maziarz, WI Bensinger… - Bone marrow …, 2010 - nature.com
Plerixafor, a novel CXCR4 inhibitor, is effective in mobilizing PBSCs particularly when used
in conjunction with G-CSF. In four cohorts, this pilot study explored the safety of plerixafor …

Peripheral blood progenitor cell mobilization using stem cell factor in combination with filgrastim in breast cancer patients

JA Glaspy, EJ Shpall, CF LeMaistre… - Blood, The Journal …, 1997 - ashpublications.org
The safety and optimal dose and schedule of stem cell factor (SCF) administered in
combination with filgrastim for the mobilization of peripheral blood progenitor cells (PBPCs) …

Pharmacodynamics and pharmacokinetics of single doses of subcutaneous pegylated human G‐CSF mutant (Ro 25‐8315) in healthy volunteers: Comparison with …

P van der Auwera, E Platzer, ZX Xu… - American journal of …, 2001 - Wiley Online Library
Ro 25‐8315 is produced by conjugation of rhG‐CSF mutant with polyethylene glycol (PEG).
The purpose of this study was to examine the pharmacodynamics and pharmacokinetics of …

A randomized phase 2 study of PBPC mobilization by stem cell factor and filgrastim in heavily pretreated patients with Hodgkin's disease or non-Hodgkin's lymphoma

P Stiff, R Gingrich, S Luger, MR Wyres… - Bone marrow …, 2000 - nature.com
This randomized, controlled study compared the ability to mobilize and collect an optimal
target yield of 5× 10 6 CD34+ cells/kg using stem cell factor (SCF; 20 μg/kg/day) plus …

A randomized phase 3 study of peripheral blood progenitor cell mobilization with stem cell factor and filgrastim in high-risk breast cancer patients

EJ Shpall, CA Wheeler, SA Turner… - Blood, The Journal …, 1999 - ashpublications.org
This randomized study compared the number of leukaphereses required to collect an
optimal target yield of 5× 106CD34+ peripheral blood progenitor cells/kg, using either stem …

Effect of CD34+ cell dose on hematopoietic reconstitution and outcome in 508 patients with multiple myeloma undergoing autologous peripheral blood stem cell …

J Klaus, D Herrmann, I Breitkreutz… - European journal of …, 2007 - Wiley Online Library
Background: We analyzed the hematopoietic reconstitution and outcome of 508 patients
with multiple myeloma (MM) with respect to the number of CD34+ cells reinfused at our …