Renal fibrosis is the final common pathophysiological pathway in chronic kidney disease
(CKD) regardless of the underlying cause of kidney injury. Tubulointerstitial fibrosis (TIF) is …

Biomarker development, improvement, and clinical implementation in the context of kidney
disease have been a central focus of biomedical research for decades. To this point, only …

Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …

Background Nephron number can be estimated from glomerular density and cortical
volume. However, because of measurement biases, this approach needs refinement …

Acute kidney injury (AKI) remains a complex challenge with diverse underlying pathological
mechanisms and etiologies. Current detection methods predominantly rely on serum …

Background Uromodulin is a protein made only by the kidney and released in urine,
circulating in polymerizing and nonpolymerizing forms. This protein's multiple functions …

Background Whether biomarkers of tubular injury and inflammation indicate subclinical
structural kidney pathology early in type 1 diabetes remains unknown. Methods We …

Cisplatin (CP) induces acute kidney injury (AKI) whereby proximal tubules undergo
regulated necrosis. Repair is almost complete after a single dose. We now demonstrate a …

Uromodulin: more than a marker for chronic kidney disease pr... : Current Opinion in Nephrology
and Hypertension Uromodulin: more than a marker for chronic kidney disease progression …

Effective management of chronic kidney disease (CKD), a major health problem worldwide,
requires accurate and timely diagnosis, prognosis of progression, assessment of therapeutic …