[HTML][HTML] How zinc-binding systems, expressed by human pathogens, acquire zinc from the colonized host environment: a critical review on zincophores

D Bellotti, M Rowińska-Żyrek… - Current Medicinal …, 2021 - ncbi.nlm.nih.gov
Some transition metals, like manganese, iron, cobalt, nickel, copper and zinc, required for
the biosynthesis of metalloenzymes and metalloproteins, are essential micronutrients for the …

Potential factors involved in the early pathogenesis of Streptococcus uberis mastitis: a review

AS Fessia, LM Odierno - Folia Microbiologica, 2021 - Springer
Bovine mastitis is an inflammation of the mammary gland, which could be the result of
allergy, physical trauma, or invasion by pathogens as Streptococcus uberis. This pathogen …

The Adc/Lmb system mediates zinc acquisition in Streptococcus agalactiae and contributes to bacterial growth and survival

P Moulin, K Patron, C Cano, MA Zorgani… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT The Lmb protein of Streptococcus agalactiae is described as an adhesin that
binds laminin, a component of the human extracellular matrix. In this study, we revealed a …

Identification of Zinc-Dependent Mechanisms Used by Group B Streptococcus To Overcome Calprotectin-Mediated Stress

LR Burcham, Y Le Breton, JN Radin, BL Spencer… - Mbio, 2020 - Am Soc Microbiol
Nutritional immunity is an elegant host mechanism used to starve invading pathogens of
necessary nutrient metals. Calprotectin, a metal-binding protein, is produced abundantly by …

Increased Zinc Availability Enhances Initial Aggregation and Biofilm Formation of Streptococcus pneumoniae

LR Brown, RC Caulkins, TE Schartel… - Frontiers in cellular …, 2017 - frontiersin.org
Bacteria growing within biofilms are protected from antibiotics and the immune system.
Within these structures, horizontal transfer of genes encoding virulence factors, and …

Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae

AG Turner, YO Cheryl-lynn, MJ Walker… - Advances in microbial …, 2017 - Elsevier
Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions
including proper innate immune function. The host immune system has complicated and …

Group A Streptococcus AdcR regulon participates in bacterial defense against host-mediated zinc sequestration and contributes to virulence

N Makthal, H Do, BM Wendel, RJ Olsen… - Infection and …, 2020 - Am Soc Microbiol
Colonization by pathogenic bacteria depends on their ability to overcome host nutritional
defenses and acquire nutrients. The human pathogen group A streptococcus (GAS) …

Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae

ML Župan, Z Luo, K Ganio, VG Pederick… - Frontiers in Cellular …, 2021 - frontiersin.org
Streptococcus pneumoniae scavenges essential zinc ions from the host during colonization
and infection. This is achieved by the ATP-binding cassette transporter, AdcCB, and two …

Zinc import mediated by AdcABC is critical for colonization of the dental biofilm by Streptococcus mutans in an animal model

T Ganguly, AM Peterson, JK Kajfasz… - Molecular oral …, 2021 - Wiley Online Library
Trace metals are essential to all domains of life but toxic when found at high concentrations.
Although the importance of iron in host–pathogen interactions is firmly established …

The adcA and lmb Genes Play an Important Role in Drug Resistance and Full Virulence of Streptococcus suis

M Peng, Y Xu, B Dou, F Yang, Q He, Z Liu… - Microbiology …, 2023 - Am Soc Microbiol
Streptococcus suis is an recognized zoonotic pathogen of swine and severely threatens
human health. Zinc is the second most abundant transition metal in biological systems …