Recent advances in therapeutic targets identification and development of treatment strategies towards Pseudomonas aeruginosa infections
DRA Sanya, D Onésime, G Vizzarro, N Jacquier - BMC microbiology, 2023 - Springer
The opportunistic human pathogen Pseudomonas aeruginosa is the causal agent of a wide
variety of infections. This non-fermentative Gram-negative bacillus can colonize zones …
variety of infections. This non-fermentative Gram-negative bacillus can colonize zones …
Microbial community evolution and functional trade-offs of biofilm in odor treatment biofilters
YC Wang, YH Lv, C Wang, GY Jiang, MF Han, JG Deng… - Water Research, 2023 - Elsevier
Biofilters inoculated with activated sludge are widely used for odor control in WWTP. In this
process, biofilm community evolution plays an important role in the function of reactor and is …
process, biofilm community evolution plays an important role in the function of reactor and is …
Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance
The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …
within patients and how these vary across bacterial infections are poorly understood …
Impact of transient acquired hypermutability on the inter- and intra-species competitiveness of Pseudomonas aeruginosa
Once acquired, hypermutation is unrelenting, and in the long-term, leads to impaired fitness
due to its cumulative impact on the genome. This raises the question of why hypermutators …
due to its cumulative impact on the genome. This raises the question of why hypermutators …
A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing
SW Miranda, EP Greenberg - Journal of Bacteriology, 2023 - Am Soc Microbiol
Many bacterial species communicate and cooperate with kin using a form of cell-cell
signaling called quorum sensing. Sensitivity and selectivity are fundamental properties of …
signaling called quorum sensing. Sensitivity and selectivity are fundamental properties of …
Adaptive Evolution of Pseudomonas aeruginosa in Human Airways Shows Phenotypic Convergence Despite Diverse Patterns of Genomic Changes
A Espaillat, CA Colque, D Rago… - Molecular Biology …, 2024 - academic.oup.com
Selective forces in the environment drive bacterial adaptation to novel niches, choosing the
fitter variants in the population. However, in dynamic and changing environments, the …
fitter variants in the population. However, in dynamic and changing environments, the …
Testing for the fitness benefits of natural transformation during community-embedded evolution
Natural transformation is a process where bacteria actively take up DNA from the
environment and recombine it into their genome or reconvert it into extra-chromosomal …
environment and recombine it into their genome or reconvert it into extra-chromosomal …
Co-occurring microflora and mucin drive Pseudomonas aeruginosa diversification and pathoadaptation
While several environmental factors contribute to the evolutionary diversification of the
pathogenic bacterium Pseudomonas aeruginosa during cystic fibrosis lung infections …
pathogenic bacterium Pseudomonas aeruginosa during cystic fibrosis lung infections …
The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection
Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …
Solving polymicrobial puzzles: evolutionary dynamics and future directions
A Srinivasan, A Sajeevan, S Rajaramon… - Frontiers in Cellular …, 2023 - frontiersin.org
Polymicrobial infections include various microorganisms, often necessitating different
treatment methods than a monomicrobial infection. Scientists have been puzzled by the …
treatment methods than a monomicrobial infection. Scientists have been puzzled by the …