Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?

G Milne, T Hames, C Scotton, N Gent… - The Lancet …, 2021 - thelancet.com
Many nations are pursuing the rollout of SARS-CoV-2 vaccines as an exit strategy from
unprecedented COVID-19-related restrictions. However, the success of this strategy relies …

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

CJ Reynolds, C Pade, JM Gibbons, AD Otter, KM Lin… - Science, 2022 - science.org
The Omicron, or Pango lineage B. 1.1. 529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

L Swadling, MO Diniz, NM Schmidt, OE Amin… - Nature, 2022 - nature.com
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some …

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

CJ Reynolds, C Pade, JM Gibbons, DK Butler, AD Otter… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine rollout has
coincided with the spread of variants of concern. We investigated whether single-dose …

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

CJ Reynolds, JM Gibbons, C Pade, KM Lin… - Science, 2022 - science.org
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …

The past, current and future epidemiological dynamic of SARS-CoV-2

F Balloux, C Tan, L Swadling, D Richard… - Oxford Open …, 2022 - academic.oup.com
Abstract SARS-CoV-2, the agent of the COVID-19 pandemic, emerged in late 2019 in China,
and rapidly spread throughout the world to reach all continents. As the virus expanded in its …

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

CJ Reynolds, L Swadling, JM Gibbons, C Pade… - Science …, 2020 - science.org
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-
2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody …

The durability of natural infection and vaccine-induced immunity against future infection by SARS-CoV-2

JP Townsend, HB Hassler, P Sah… - Proceedings of the …, 2022 - National Acad Sciences
The durability of vaccine-mediated immunity to SARS-CoV-2, the durations to breakthrough
infection, and the optimal timings of booster vaccination are crucial knowledge for pandemic …

A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma

D Najjar, J Rainbow, S Sharma Timilsina… - Nature biomedical …, 2022 - nature.com
Rapid, accurate and frequent detection of the RNA of SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2) and of serological host antibodies to the virus would facilitate the …

[HTML][HTML] Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections

A Chandran, J Rosenheim, G Nageswaran… - Cell Reports …, 2022 - cell.com
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of
protective immunity to future variants, but we lack insights into immune responses before or …