The antitumor activity of bromodomain and extraterminal motif protein inhibitors (BETi) has
been demonstrated across numerous types of cancer. As such, these inhibitors are currently …

Purpose Durable and long-term responses to the poly (ADP-ribose) polymerase inhibitor
olaparib are observed in patients without BRCA1/2 mutations. However, beyond BRCA1/2 …

The repair of DNA double-strand breaks (DSBs) is mediated via two major pathways,
nonhomologous end joining (NHEJ) and homologous recombination (HR) repair. DSB …

The t rans m embrane e mp24 d omain/p24 (TMED) family are essential components of the
vesicular transport machinery. Members of the TMED family serve as cargo receptors …

Abstract Poly (ADP-ribosylation), known as PARylation, is a post-translational modification
catalyzed by poly (ADP-ribose) polymerases (PARP) and primarily removed by the enzyme …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1), a critical DNA repair protein, is
frequently upregulated in breast tumors with a key role in breast cancer progression …

In an attempt to clarify the prognostic relevance of poly (ADP-ribose) polymerase (PARP)
expression, we analysed the clinical data of 86 high-grade epithelial ovarian cancer (EOC) …

Background Poly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of
PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair …

Targeting Poly (ADP-ribose) polymerase 1 (PARP-1) involved in base excision repair (BER)
has been shown to be a clinically effective treatment strategy in epithelial ovarian cancer …

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but often lethal
cancer that is diagnosed at a median age of 24 years. Optimal management of patients is …