To protect tissues and the organism from disease, potentially harmful cells are removed
through programmed cell death processes, including apoptosis and necroptosis. These …

Constitutive expression of interferons (IFNs) and activation of their signaling pathways have
pivotal roles in host responses to malignant cells in the tumor microenvironment. IFNs are …

Purpose: Pelareorep is an intravenously delivered oncolytic reovirus that can induce a T-cell–
inflamed phenotype in pancreatic ductal adenocarcinoma (PDAC). Tumor tissues from …

Background We hypothesised that host-response biomarkers of viral infections might
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …

Cereblon (CRBN), a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is
the target of the immunomodulatory drugs lenalidomide and pomalidomide. Recently, it was …

Transcriptional profiles and host-response biomarkers are used increasingly to investigate
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …

In the past few years, chimeric antigen receptor (CAR) T-cell therapy has emerged as a
promising treatment for cancers that failed standard treatments. Such therapies have already …

Airway epithelial cells (AECs) provide the first line of defense in the respiratory tract and are
the main target of respiratory viruses. Here, using oligonucleotide and protein arrays, we …

Discovered as antiviral cytokines, interferons (IFNs) are now also recognized for their
capacity to inhibit the growth of malignant cells via activation of programmed cell death …

Interferons establish an antiviral state through the induction of hundreds of interferon-
stimulated genes (ISGs). The mechanisms and viral specificities for most ISGs remain …