Intratumoral approaches for the treatment of melanoma
There have been significant advances in the immunotherapy of melanoma over the last
decade. The tumor microenvironment is now known to promote an immune-suppressive …
decade. The tumor microenvironment is now known to promote an immune-suppressive …
Oral administration of soluble β‐glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor …
Y Masuda, H Inoue, H Ohta, A Miyake… - … Journal of Cancer, 2013 - Wiley Online Library
Maitake D (MD)‐Fraction is a highly purified soluble β‐glucan derived from Grifola frondosa
(an oriental edible mushroom). Intraperitoneal (ip) injection of MD‐Fraction has been …
(an oriental edible mushroom). Intraperitoneal (ip) injection of MD‐Fraction has been …
Higher numbers of T-bet+ intratumoral lymphoid cells correlate with better survival in gastric cancer
L Chen, X Zheng, Y Shen, Y Zhu, Q Li, J Chen… - Cancer Immunology …, 2013 - Springer
In the present study, we studied the expression of T-bet, a key marker for type 1 immune
responses, within the tumor microenvironment of gastric cancer, and analyzed its …
responses, within the tumor microenvironment of gastric cancer, and analyzed its …
The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape
B Seliger, C Massa - Frontiers in immunology, 2013 - frontiersin.org
Dendritic cells (DC) play a central role in the regulation of the immune responses by
providing the information needed to decide between tolerance, ignorance, or active …
providing the information needed to decide between tolerance, ignorance, or active …
T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract
B Lu, L Chen, L Liu, Y Zhu, C Wu, J Jiang… - Immunologic …, 2011 - Springer
Tumorigenesis can induce adaptive T-cell-mediated immune responses against malignant
cells. Such cellular immune responses are actively suppressed by cancer cells via …
cells. Such cellular immune responses are actively suppressed by cancer cells via …
Combined vaccine+ axitinib therapy yields superior antitumor efficacy in a murine melanoma model
Axitinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptors, has
demonstrated modest efficacy when applied as a single agent in the setting of advanced …
demonstrated modest efficacy when applied as a single agent in the setting of advanced …
Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity
Y Masuda, D Nawa, Y Nakayama… - Journal of Leucocyte …, 2015 - academic.oup.com
The maturation of dendritic cells into more-immunostimulatory dendritic cells by stimulation
with different combinations of immunologic agents is expected to provide efficient, adoptive …
with different combinations of immunologic agents is expected to provide efficient, adoptive …
Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells
Murine dendritic cells (DC) transduced to express the Type-1 transactivator T-bet (ie mDC.
Tbet) and delivered intratumorally as a therapy are superior to control wild-type DC in …
Tbet) and delivered intratumorally as a therapy are superior to control wild-type DC in …
Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses
D Raïch-Regué, KP Fabian, AR Watson… - …, 2016 - Taylor & Francis
Dendritic cells (DC) play a pivotal role in the induction and regulation of immune responses.
In cancer, DC-based vaccines have proven to be safe and to elicit protective and therapeutic …
In cancer, DC-based vaccines have proven to be safe and to elicit protective and therapeutic …
Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma
S Ludwig, CS Hong, BM Razzo, KPL Fabian… - Cancer Immunology …, 2019 - Springer
Advanced oral squamous cell carcinomas (OSCC) have limited therapeutic options.
Although immune therapies are emerging as a potentially effective alternative or adjunct to …
Although immune therapies are emerging as a potentially effective alternative or adjunct to …