[HTML][HTML] Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: A systematic review
Tyrosinase is a multifunctional glycosylated and copper-containing oxidase that is highly
prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of …
prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of …
Recent advances in the design and discovery of synthetic tyrosinase inhibitors
J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
Lead optimization of BIBR1591 to improve its telomerase inhibitory activity: design and synthesis of novel four chemical series with in silico, in vitro, and in vivo …
AA Al-Karmalawy, MHA Mousa… - Journal of Medicinal …, 2023 - ACS Publications
Herein, modifications to the previously reported BIBR1591 were conducted to obtain
bioisosteric candidates with improved activities. The% inhibition of the newly afforded …
bioisosteric candidates with improved activities. The% inhibition of the newly afforded …
Molecular docking, synthesis, and tyrosinase inhibition activity of acetophenone amide: Potential inhibitor of melanogenesis
Tyrosinase and its related proteins are responsible for pigmentation disorders, and inhibiting
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …
Design, synthesis, and structural characterization of thioflavones and thioflavonols as potential tyrosinase inhibitors: In vitro and in silico studies
To find new potential tyrosinase inhibitors, a diverse range of 2-arylchromone-4-thione
derivatives (2a–2p) were designed and synthesized by employing a multistep strategy, and …
derivatives (2a–2p) were designed and synthesized by employing a multistep strategy, and …
In silico and in vitro studies of novel derivatives of tyrosol and raspberry ketone as the mushroom tyrosinase inhibitors
Tyrosinase is the key enzyme for melanin biosynthesis. Overproduction and deposition of
this pigment cause different problems in various industries including agriculture and food …
this pigment cause different problems in various industries including agriculture and food …
Synthesis and biological evaluation of substituted aurone derivatives as potential tyrosinase inhibitors: in vitro, kinetic, QSAR, docking and drug-likeness studies
NA Alshaye, EU Mughal, EB Elkaeed… - Journal of …, 2023 - Taylor & Francis
Tyrosinase enzyme plays an essential role in melanin biosynthesis and enzymatic browning
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
Evaluation of 2,3-Dihydro-1,5-benzothiazepine Derivatives as Potential Tyrosinase Inhibitors: In Vitro and In Silico Studies
Benzothiazepines are pharmacologically active compounds, frequently utilized as a
precursor for acquiring versatile molecules with several bioactivities including anti …
precursor for acquiring versatile molecules with several bioactivities including anti …
Medicinal prospects of targeting tyrosinase: A feature review
Y Wang, B Xiong, S Xing, Y Chen… - Current Medicinal …, 2023 - ingentaconnect.com
Tyrosinase is a bifunctional polyphenol oxidase (PPO), catalyzing two oxidative reactions:
monophenols to o-quinones (monophenolase activity) and o-diphenols to oquinones …
monophenols to o-quinones (monophenolase activity) and o-diphenols to oquinones …
[HTML][HTML] Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies
As part of our continuous search for novel tyrosinase inhibitors, we designed 5, 6-
dihydroimindazo [2, 1-b] thiazol-3 (2H)-one (DHIT) derivatives based on the structure of …
dihydroimindazo [2, 1-b] thiazol-3 (2H)-one (DHIT) derivatives based on the structure of …