Striated muscle: an inadequate soil for cancers

AAE Saunders, RE Thomson, CA Goodman… - Cancer and Metastasis …, 2024 - Springer
Many organs of the body are susceptible to cancer development. However, striated muscles—
which include skeletal and cardiac muscles—are rarely the sites of primary cancers. Most …

Disparities in cancer genetic testing and variants of uncertain significance in the Hispanic population of South Texas

S Soewito, R Wyatt, E Berenson, N Poullard… - JCO Oncology …, 2022 - ascopubs.org
PURPOSE: Racial and ethnic disparities have included a lack of access to both genetic
testing and research, resulting in poor understanding of the genomic architecture in under …

tp53 R217H and R242H Mutant Zebrafish Exhibit Dysfunctional p53 Hallmarks and Recapitulate Li-Fraumeni Syndrome Phenotypes

K Kobar, JN Berman, JA Fiene, L Tuzi, E Burnley… - bioRxiv, 2024 - biorxiv.org
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome associated with
a highly penetrant cancer spectrum characterized by germline TP53 mutations. We …