The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Connexin family proteins assemble into hexameric hemichannels in the cell membrane. The
hemichannels dock together between two adjacent membranes to form gap junction …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Connexin hemichannels were identified as the first members of the eukaryotic large-pore
channel family that mediate permeation of both atomic ions and small molecules between …

Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …

Abstract Connexin 36 (Cx36) is responsible for signal transmission in electrical synapses by
forming interneuronal gap junctions. Despite the critical role of Cx36 in normal brain …

Cryogenic electron microscopy (cryo-EM) has now been widely used for determining
multichain protein complexes. However, modeling a large complex structure, such as those …

Connexin family proteins assemble into hexameric channels called hemichannels/
connexons, which function as transmembrane channels or dock together to form gap …