Aortic valve stenosis due to calcification of the valve leaflets is the most common valve
disease in the developed world. It is the third leading cause of cardiovascular disease. 1 …

Despite the focus placed on cardiovascular research, the prevalence of vascular and
valvular calcification is increasing and remains a leading contributor of cardiovascular …

Inflammation, the primary response of innate immunity, is essential to initiate the calcification
process underlying calcific aortic valve disease (CAVD), the most prevalent valvulopathy in …

Calcific Aortic Valve Disease (CAVD) is the most common heart valve disease and its
incidence is expected to rise with aging population. No medical treatment so far has shown …

Calcific aortic valve disease (CAVD) is prevalent in developed nations and has emerged as
a pressing global public health concern due to population aging. The precise etiology of this …

Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed
world with currently no effective pharmacological treatment available. CAVD results from a …

Despite the elucidation of the pathways behind the development of aortic stenosis (AS),
there remains no effective medical treatment to slow or reverse its progress. Instead, the …

Background: Aortic valve calcification is an active proliferative process, where interstitial
cells of the valve transform into either myofibroblasts or osteoblast-like cells causing valve …

Calcific aortic valve disease (CAVD) is a complex active process involving in endothelial
injury, lipid infiltration, chronic inflammation, matrix remodeling, cell differentiation …

Elevated low-density lipoprotein (LDL) concentration in mid-life increases the risk of
developing Alzheimer's disease (AD) in later life. Increased oxidized LDL (oxLDL) …