Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

This year in review about osteoarthritis biology highlights a selection of articles published
between the 2019 and 2020 Osteoarthritis Research Society International (OARSI) World …

Abstract Purpose of Review Metformin has multiple benefits for health beyond its anti-
hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that …

Objectives Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases
that frequently co-exist, along with overweight/obesity. While the mechanical impact of …

Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with
significant burden on the individual and society. It is a severe disease for its high disability …

In spite of a major public health burden with increasing prevalence, current osteoarthritis
(OA) management is largely palliative with an unmet need for effective treatment. Both …

The rising prevalence of osteoarthritis (OA) in the general population has necessitated the
development of novel treatment options. It is critical to recognize the joint as a separate …

Obesity and insulin resistance are two major risk factors for the development of metabolic
syndrome, type 2 diabetes and associated cardiovascular diseases (CVDs) …

Objective Obesity is a risk factor for knee osteoarthritis (KOA) development and progression.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are indicated for type 2 diabetes …