Our increasing appreciation of the importance of inflammation in vascular disease has
focused attention on the molecules that direct the migration of leukocytes from the blood …

Large DNA viruses defend against hostile assault executed by the host immune system by
producing an array of gene products that systematically sabotage key components of the …

Viruses have evolved elegant mechanisms to evade detection and destruction by the host
immune system. One of the evasion strategies that have been adopted by large DNA viruses …

▪ Abstract Immune modulators such as cytokines and growth factors exert their biological
activity through high-affinity interactions with cell-surface receptors, thereby activating …

The chemokine superfamily of leukocyte chemo-attractants coordinates development and
deploy-ment of the immune system by signaling through a family of G protein–coupled …

Myxoma virus is a poxvirus naturally found in two American leporid (rabbit) species
(Sylvilagus brasiliensis and Sylvilagus bachmani) in which it causes an innocuous localised …

Interleukins are considered to be key players in the chronic vascular inflammatory response
that is typical of atherosclerosis. Thus, the expression of proinflammatory interleukins and …

Successful transmission by viruses in the face of vigorous innate and acquired host
immunity requires the ability to evade, obstruct, or subvert critical elements that mediate host …

Periodontal disease (PD) and atherosclerosis are both polymicrobial and multifactorial and
although observational studies supported the association, the causative relationship …

In the past year, important advances have been made in the area of host-related
immunomodulatory genes encoded by the larger DNA viruses, particularly for the poxviruses …