The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Detyrosinated microtubules provide mechanical resistance that can impede the motion of
contracting cardiomyocytes. However, the functional effects of microtubule detyrosination in …

Mitochondrial dysfunction is a hallmark of heart failure. Mitochondrial transplantation has
been demonstrated to be able to restore heart function, but its mechanism of action remains …

Highlights•Mitochondrial dynamics depend on interactions with the cytoskeleton.•
Interactions with microtubules mediate motility, turnover, and organelle inheritance.• …

The ability of a mitochondrion to undergo fission and fusion, and to be transported and
localized within a cell are central not just to proper functioning of mitochondria, but also to …

Metabolism and mechanics are two key facets of structural and functional processes in cells,
such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has …

In the past decades, the cardiovascular community has laid out the fundamental signaling
cascades that become awry in the cardiomyocyte during the process of pathologic cardiac …

Microtubules, a highly dynamic cytoskeleton, participate in many cellular activities including
mechanical support, organelles interactions, and intracellular trafficking. Microtubule …

It has been shown that growth hormone-releasing hormone (GHRH) reduces cardiomyocyte
(CM) apoptosis, prevents ischemia/reperfusion injury, and improves cardiac function in …