Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic
homeostasis of this essential trace element. This review summarizes the key aspects of …

Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Altered intestinal permeability plays a role in many pathological conditions. Intestinal
permeability is a component of the intestinal barrier. This barrier is a dynamic interface …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Although manganese is an essential trace metal, little is known about its transport and
homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal …

Sepsis is a systemic inflammatory condition caused by an unbalanced immunological
response to infection, which affects numerous organs, including the intestines …

Zinc is an essential trace element for living organisms, and zinc homeostasis is essential for
the maintenance of the normal physiological functions of cells and organisms. The intestine …

Introduction Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's
disease (CD), is a group of chronic recurrent and incurable gastrointestinal diseases with an …

Although manganese (Mn) is critical for the proper functioning of various metabolic enzymes
and cofactors, excess Mn in the brain causes neurotoxicity. While the exact transport …

Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-
transport protein that serves a critical role in erythroid iron utilization. We have investigated …