The recent progress in biomaterials science and development of tubular conduits (TCs) still
fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in …

The Seddon and Sunderland classifications have been used by physicians for peripheral
nerve injury grading and treatment. While Seddon classification is simpler to follow and …

Introduction: The clinical use of tacrolimus is characterized by many side effects which
include neurotoxicity. In contrast, tacrolimus has also shown to have neuroregenerative …

Representing the treatment and management philosophy of Dr. Susan Mackinnon, Nerve
Surgery provides extensive coverage of innovative surgical options as well as guidance on …

Administration of FK506, an FDA approved immunosuppressant, has been shown to
enhance nerve regeneration following peripheral nerve injuries. However, the severe side …

Exosomes secreted by adipose-derived stem cells (ADSC-exo) reportedly improve nerve
regeneration after peripheral nerve injury. Herein, we investigated whether pretreatment of …

The acceleration of peripheral nerve regeneration is crucial for functional nerve recovery.
Our previous study demonstrated that human Wharton's jelly-derived mesenchymal stem …

Background Attempts to improve limb preservation for transplantation using ex vivo
perfusion have yielded promising results. However, metabolic acidosis, aberrant perfusate …

Upper limb transplantation has become a treatment option for upper limb amputees with
good midterm results. Lower extremity transplantation has never been considered for fear of …

Cell therapy for spinal cord injury (SCI) is a promising strategy for clinical application.
Mesenchymal stem cells (MSC) have demonstrated beneficial effects following …