Application of (4+ 3) cycloaddition strategies in the synthesis of natural products

Z Yin, Y He, P Chiu - Chemical Society Reviews, 2018 - pubs.rsc.org
(4+ 3) Cycloadditions have been widely applied in synthesis, and in this review article, we
summarize some of the more recent applications, including formal (4+ 3) cycloadditions, in …

An overview of synthetic approaches for heterocyclic steroids

R Singh, G Panda - Tetrahedron, 2013 - Elsevier
Steroids belong to an essential class of bioactive natural products owing to their ability to
enter cell membranes and bind to nuclear and membrane receptors. The steroidal system …

Gallium (III)‐Catalyzed Three‐Component (4+ 3) Cycloaddition Reactions

X Han, H Li, RP Hughes, J Wu - Angewandte Chemie International Edition, 2012 - infona.pl
Direct approach to indoles: The title reaction generates cyclohepta [b] indole derivatives in a
single step at room temperature (see scheme). Exclusion of air or moisture is not required …

Lewis acid catalyzed formal intramolecular [3+ 2] cross-cycloaddition of cyclopropane 1, 1-diesters with alkenes: general and efficient strategy for construction of …

W Zhu, J Fang, Y Liu, J Ren, Z Wang - Angewandte Chemie, 2013 - search.ebscohost.com
Developing efficient and general strategies to construct skeletally complex and diverse
polycyclic skeletons is important for both synthesis of natural products and chemical biology …

The versatility of furfuryl alcohols and furanoxonium ions in synthesis

MJ Palframan, G Pattenden - Chemical Communications, 2014 - pubs.rsc.org
Substituted furfuryl alcohols are extraordinarily versatile starting materials in synthesis. They
are precursors to furanoxonium ion intermediates which are implicated in the Piancatelli …

Unprecedented Reactivity of γ‐Amino Cyclopentenone Enables Diversity‐Oriented Access to Functionalized Indoles and Indole‐Annulated Ring Structures

C Jagadeesh, B Mondal, S Pramanik… - Angewandte Chemie …, 2021 - Wiley Online Library
Observation of an unexpected, Lewis acid promoted displacement of latent reactive γ‐amino
group on cyclopentenone presented unparalleled opportunity for enone functionalization …

Total synthesis of (−)-ambiguine P

J Xu, VH Rawal - Journal of the American Chemical Society, 2019 - ACS Publications
Described is a concise total synthesis of (−)-ambiguine P, a cycloheptane-containing
member of the hapalindole alkaloids. The challenging pentacyclic framework of the natural …

[PDF][PDF] Duality of Donor-Acceptor Cyclopropane Reactivity as a Three-Carbon Component in Five-Membered Ring Construction:[3+ 2] Annulation Versus [3+ 2] …

YA Volkova, EM Budynina, AE Kaplun… - Chemistry-A European …, 2013 - chem.msu.ru
The long-standing and continuous interest in efficient synthetic approaches to
cyclopentanoids stems from their value as building blocks in organic chemistry and their …

Total Synthesis of (+/−)‐Frondosin B and (+/−)‐5‐epi‐Liphagal by Using a Concise (4+3) Cycloaddition Approach

DR Laplace, B Verbraeken… - … –A European Journal, 2014 - Wiley Online Library
Abstract A recently developed (4+ 3) cycloaddition between dienes and furfuryl alcohols, as
precursors of oxyallyl‐type cations, has been used as a key step in the racemic syntheses of …

Zinc‐Catalyzed [4+3] Cycloaddition with Concomitant Furan Annulation: Formation of Cyclohepta[b]Furans

B Song, LH Li, XR Song, YF Qiu… - … A European Journal, 2014 - Wiley Online Library
Abstract A convenient zinc‐promoted [4+ 3] cycloaddition of a carbonyl ene–yne with simple
dienes was first achieved. This reaction provided an efficient strategy to prepare various …