The role of the gut microbiota in health and disease is becoming increasingly recognized.
The microbiota–gut–brain axis is a bi-directional pathway between the brain and the …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Abstract Rationale Atypical antipsychotic drugs (AAPDs) such as olanzapine have a serious
side effect profile including weight gain and metabolic dysfunction, and a number of studies …

The atypical antipsychotic olanzapine is often associated with serious metabolic side effects
including weight gain and increased visceral fat. These adverse events are a considerable …

The second-generation antipsychotic olanzapine is effective in reducing psychotic
symptoms but can cause extreme weight gain in human patients. We investigated the role of …

The significance of the gut microbiota as a determinant of drug pharmacokinetics and
accordingly therapeutic response is of increasing importance with the advent of modern …

Hypothalamic detection of elevated circulating glucose triggers suppression of endogenous
glucose production (EGP) to maintain glucose homeostasis. Antipsychotics alleviate …

Rationale: Pulmonary hypertension (PH) due to left heart disease (LHD), or group 2 PH, is
the most prevalent form of PH worldwide. PH due to LHD is often associated with metabolic …

Schizophrenia is a debilitating psychiatric disorder that is treated with antipsychotics.
However, despite their efficacy, antipsychotics increase the risk of metabolic disorders in a …

Since the serendipitous discovery of the first antipsychotic (AP) drug in the 1950s, APs
remain the cornerstone of treatment for schizophrenia. A shift over the past two decades …