Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Many cancer therapies produce toxic side effects whose molecular mechanisms await full
elucidation. The most feared and studied side effect of chemotherapeutic drugs is …

Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However,
the molecular mechanisms regulating mitochondrial functions via selective mitochondrial …

The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here,
we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …

The AMP‐activated serine/threonine protein kinase (AMPK) is a sensor of cellular energy
status found in all eukaryotes that is activated under conditions of low intracellular ATP …

Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

Regular physical activity with aerobic and muscle-strengthening training protects against the
occurrence and progression of cardiovascular disease and can improve cardiac function in …

The circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on
the heart under stress conditions. The receptors binding APN to cardiac tissue, however …