Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

Food–drug interaction studies are critical to evaluate appropriate dosing, timing, and
formulation of new drug candidates. These interactions often reflect prandial-associated …

Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …

Here we report on a high-performance electrochemical sensor for the sensitive detection of
acetaminophen based on graphene, which was simultaneously electrochemically reduced …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that undergoes
extensive phase I and II metabolism. To better understand the kinetics of this process and to …

Adverse drug reactions (ADRs) can involve all tissues and organs, but liver injuries are
considered among the most serious. A number of prospective, multicenter studies have …

Acetaminophen (APAP) hepatotoxicity remains the leading cause of drug-induced liver
injury due to the lack of safe and effective therapeutic agents. Berberine (BBR) is a natural …

Identification of genetic polymorphisms that contribute to the risk of developing cancers is
important for cancer prevention. The most recent human genome GRCh38/hg38 assembly …

Technologic advances now make it possible to collect large amounts of genetic, epigenetic,
metabolomic and gut microbiome data. These data have the potential to transform …

The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop
strategies for using all available data (in vitro, in vivo, and in silico) to advance the next …