Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an
incurable, progressive neurodegenerative disorder. Current treatment of the disease …

The WHO Nomenclature Committee for Factors of the HLA System met following the 14th
International HLA and Immunogenetics Workshop in Melbourne, Australia in December …

Transcriptome-wide association studies using predicted expression have identified
thousands of genes whose locally regulated expression is associated with complex traits …

The finding that a GGGGCC (G4C2) hexanucleotide repeat expansion in the chromosome 9
ORF 72 (C9ORF72) gene is a common cause of amyotrophic lateral sclerosis (ALS) and …

Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has
hampered sequencing and associated evolutionary studies. Here we trace Y evolution …

Many prokaryotic species generate hydrogen sulfide (H2S) in their natural environments.
However, the biochemistry and physiological role of this gas in nonsulfur bacteria remain …

The sequence of the human genome encodes the genetic instructions for human
physiology, as well as rich information about human evolution. In 2001, the International …

We report the application of single-molecule-based sequencing technology for high-
throughput profiling of histone modifications in mammalian cells. By obtaining over four …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

This study describes comprehensive polling of transcription start and termination sites and
analysis of previously unidentified full-length complementary DNAs derived from the mouse …