A long-standing question in evolutionary and developmental biology concerns the relative
contribution of cis-regulatory and protein changes to developmental evolution. Central to this …

Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with
active transcription in mammalian cells. Here we report that the chromodomain Y-like …

Previously, we reported that chromodomain Y–like (CDYL) acts as a crotonyl–coenzyme A
hydratase and negatively regulates histone crotonylation (Kcr). However, the global CDYL …

Transgenic animal models have played an important role in elucidating gene functions and
the molecular basis development, physiology, behavior, and pathogenesis. Transgenic …

Background Major depressive disorder is a prevalent and life-threatening illness in modern
society. The susceptibility to major depressive disorder is profoundly influenced by …

Polycomb group proteins play essential roles in transcriptional regulation of multiple gene
families involved in various pathophysiological processes. It is believed that Polycomb …

Chimeric RNAs have been reported in varieties of organisms and are conventionally thought
to be produced by trans-splicing of two or more distinct transcripts. Here, we conducted a …

Dendritic arborization is one of the key determinants of precise circuits for information
processing in neurons. Unraveling the molecular mechanisms underlying dendrite …

Proteins containing defined recognition modules mediate readout and translation of histone
modifications. These factors are thought to initiate downstream signaling events regulating …

Chromodomain Y (CDY) is one of the candidate genes for male dyszoospermia related to Y
chromosome microdeletion (YCM). However, the function of CDY in regulating …