BACKGROUND Nature has evolved elegant mechanisms to regulate the physical distance
between molecules, or proximity, for a wide variety of purposes. Whether it is activation of …

As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or
mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress …

Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have
been identified for many human cancers,,–. Independent studies have identified cell death …

Immunotherapy with T cells expressing the chimeric antigen receptor (CAR) specific for the
CD19 antigen (CD19. CAR-Ts) is a very effective treatment in B cell lymphoid malignancies …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

Caspases, which are the executioners of apoptosis, comprise two distinct classes, the
initiators and the effectors. Although general structural features are shared between the …

To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we
transduced T lymphocytes with anti-CD19 chimeric receptors, consisting of an anti-CD19 …

Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase
recruitment domain (CARD) linked to a nucleotide-binding domain, which regulate …

Apoptosis, a morphologically defined form of physiological cell death, is implemented by a
death machinery whose executionary arm is a family of cysteine proteases called caspases …