Polymeric in situ forming depots for long-acting drug delivery systems
Polymeric in situ forming depots have emerged as highly promising drug delivery systems
for long-acting applications. Their effectiveness is attributed to essential characteristics such …
for long-acting applications. Their effectiveness is attributed to essential characteristics such …
Recent advances in intranasal administration for brain-targeting delivery: a comprehensive review of lipid-based nanoparticles and stimuli-responsive gel formulations
J Koo, C Lim, KT Oh - International Journal of Nanomedicine, 2024 - Taylor & Francis
Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
Liposome-derived nanosystems for the treatment of behavioral and neurodegenerative diseases: the promise of niosomes, transfersomes, and ethosomes for …
PC Pires, AC Paiva-Santos, F Veiga - Pharmaceuticals, 2023 - mdpi.com
Psychiatric and neurodegenerative disorders are amongst the most prevalent and
debilitating diseases, but current treatments either have low success rates, greatly due to the …
debilitating diseases, but current treatments either have low success rates, greatly due to the …
Nanovesicular-mediated intranasal drug therapy for neurodegenerative disease
S Singh, R Shukla - AAPS PharmSciTech, 2023 - Springer
Numerous neurodegenerative conditions, such as Alzheimer's, Huntington's, Parkinson's,
amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant …
amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant …
Research progress in brain-targeted nasal drug delivery
Q Huang, X Chen, S Yu, G Gong, H Shu - Frontiers in Aging …, 2024 - frontiersin.org
The unique anatomical and physiological connections between the nasal cavity and brain
provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted …
provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted …
Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2
Purpose Immunomodulatory and broad-spectrum antiviral activities have motivated the
evaluation of curcumin for Coronavirus infection 2019 (COVID-19) management. Inadequate …
evaluation of curcumin for Coronavirus infection 2019 (COVID-19) management. Inadequate …
Cross-linked alginate dialdehyde/chitosan hydrogel encompassing curcumin-loaded bilosomes for enhanced wound healing activity
The current study aimed to fabricate curcumin-loaded bilosomal hydrogel for topical wound
healing purposes, hence alleviating the poor aqueous solubility and low oral bioavailability …
healing purposes, hence alleviating the poor aqueous solubility and low oral bioavailability …
Synergistic approach for acne vulgaris treatment using glycerosomes loaded with lincomycin and lauric acid: Formulation, in silico, in vitro, LC-MS/MS skin deposition …
This study aims to develop a pharmaceutical formulation that combines the potent
antibacterial effect of lincomycin and lauric acid against Cutibacterium acnes (C. acnes), a …
antibacterial effect of lincomycin and lauric acid against Cutibacterium acnes (C. acnes), a …
Exploitation of transdermal nanobilosomal gel platforms for ameliorating anti-diabetic activity of empagliflozin following I-optimal design
TM Ibrahim - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
The current study aimed to optimize a bilosomal gel (bilo-gel) formulation loaded with anti-
diabetic empagliflozin. Enhancement of transdermal delivery of empagliflozin was targeted …
diabetic empagliflozin. Enhancement of transdermal delivery of empagliflozin was targeted …
Terpene-augmented novasomal gels for the sustainment of rasagiline mesylate delivery; A new approach for treating Parkinson's disease induced by rotenone in rats
HN ElShagea, RR Makar, AH Salama… - Journal of Drug Delivery …, 2024 - Elsevier
Rasagiline mesylate (RSM) is a potent anti-Parkinson's Disease (PD) drug; nevertheless, it
has limited oral bioavailability due to hepatic first pass metabolism. RSM is a highly …
has limited oral bioavailability due to hepatic first pass metabolism. RSM is a highly …