The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …

New methods for automatic image segmentation, and prediction of fracture risk show
promising clinical value. Though these recent developments have had a successful initial …

Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …

The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and
other lineages are known to be controlled by various extrinsic and intrinsic signals. The …

Remodelling of energy storing white fat into energy expending beige fat could be a
promising strategy to reduce adiposity. Here, we show that the bile acid-responsive …

Mesenchymal stem cell (MSC) exosomes promote tissue regeneration and repair, and thus
might be used to treat many diseases; however, the influence of microenvironmental …

Osteochondral defects are most commonly characterized by damages to both cartilage and
bone tissues as a result of serious traumas or physical diseases; because these two tissues …

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes
in bone biology, particularly to intramembranous ossification, not captured at other skeletal …

Lineage specification is an essential process in stem cell fate, tissue homeostasis and
development. Microenvironmental cues provide direct and selective extrinsic signals to …

Bone is a complex mineralized tissue composed of various organic (proteins, cells) and
inorganic (hydroxyapatite, calcium carbonate) substances with micro/nanoscale structures …