Therapeutic potential of neuropeptide Y (NPY) receptor ligands
SP Brothers, C Wahlestedt - EMBO molecular medicine, 2010 - embopress.org
Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast
number of physiological processes. Since its discovery, NPY has been implicated in …
number of physiological processes. Since its discovery, NPY has been implicated in …
Neuropeptide Y receptors: how to get subtype selectivity
X Pedragosa-Badia, J Stichel… - Frontiers in …, 2013 - frontiersin.org
The neuropeptide Y (NPY) system is a multireceptor/multiligand system consisting of four
receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate …
receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate …
Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice
JS Knight, V Subramanian, AA O'Dell… - Annals of the …, 2015 - ard.bmj.com
Objectives An imbalance between neutrophil extracellular trap (NET) formation and
degradation has been described in systemic lupus erythematosus (SLE), potentially …
degradation has been described in systemic lupus erythematosus (SLE), potentially …
GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents
J Ye, Z Hao, MB Mumphrey… - American Journal …, 2014 - journals.physiology.org
Exaggerated GLP-1 and PYY secretion is thought to be a major mechanism in the reduced
food intake and body weight after Roux-en-Y gastric bypass surgery. Here, we use …
food intake and body weight after Roux-en-Y gastric bypass surgery. Here, we use …
Neuropeptide Y and posttraumatic stress disorder
R Sah, TD Geracioti - Molecular psychiatry, 2013 - nature.com
Resiliency to the adverse effects of extraordinary emotional trauma on the brain varies within
the human population. Accordingly, some people cope better than others with traumatic …
the human population. Accordingly, some people cope better than others with traumatic …
Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD
The amygdala-dependent molecular mechanisms driving the onset and persistence of
posttraumatic stress disorder (PTSD) are poorly understood. Recent observational studies …
posttraumatic stress disorder (PTSD) are poorly understood. Recent observational studies …
Neuropeptide Y, resilience, and PTSD therapeutics
Resilience to traumatic stress is a complex psychobiological process that protects
individuals from developing posttraumatic stress disorder (PTSD) or other untoward …
individuals from developing posttraumatic stress disorder (PTSD) or other untoward …
Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder
EL Sabban, LG Alaluf, LI Serova - Neuropeptides, 2016 - Elsevier
There is extensive evidence that NPY in the brain can modulate the responses to stress and
play a critical role in resistance to, or recovery from, harmful effects of stress. Development of …
play a critical role in resistance to, or recovery from, harmful effects of stress. Development of …
Structural basis for ligand recognition of the neuropeptide YY2 receptor
T Tang, C Hartig, Q Chen, W Zhao, A Kaiser… - Nature …, 2021 - nature.com
The human neuropeptide Y (NPY) Y2 receptor (Y2R) plays essential roles in food intake,
bone formation and mood regulation, and has been considered an important drug target for …
bone formation and mood regulation, and has been considered an important drug target for …
Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY
BM Flannery, ES Clark, JJ Pestka - Toxicological sciences, 2012 - academic.oup.com
Consumption of deoxynivalenol (DON), a trichothecene mycotoxin known to commonly
contaminate grain-based foods, suppresses growth of experimental animals, thus raising …
contaminate grain-based foods, suppresses growth of experimental animals, thus raising …