BACKGROUND Cell-free fetal nucleic acids (cffNA) can be detected in the maternal
circulation during pregnancy, potentially offering an excellent method for early non-invasive …

OBJECTIVE: In contrast to the traditional teaching that the placenta forms an impermeable
barrier, multiple studies show that both intact fetal cells and cell-free nucleic acids circulate …

Objective To test the hypothesis that free fetal DNA (ffDNA) circulating in maternal plasma
originates mainly from the placenta we studied ffDNA levels in anembryonic pregnancies …

The analysis of circulating nucleic acids has revealed applications in the noninvasive
diagnosis, monitoring, and prognostication of many clinical conditions. Circulating fetal …

The kinetics and structure of cell-free fetal DNA in maternal plasma is currently under
investigation. Plasma fetal DNA seems quite stable albeit cleared rapidly following birth …

Background: Detection of fetal DNA in maternal plasma is achievable at 5 weeks of
gestation, but few large-scale studies have reported circulating fetal and maternal DNA …

Since the discovery of circulating nucleic acids in plasma in 1948, many diagnostic
applications have emerged. For example, diagnostic and prognostic potentials of circulating …

Recently, we have witnessed the rapid translation into clinical practice of non‐invasive
prenatal testing for the common aneuploidies, most notably within the United States and …

The identification of cell-free fetal DNA (cffDNA) in maternal plasma in 1997 heralded the
most significant change in obstetric care for decades, with the advent of safer screening and …

Chromosomal abnormalities are responsible for a significant number of birth defects,
including mental retardation. The present invention is related to methods for non-invasive …