Postmenopausal osteoporosis is the most common bone disease, associated with low bone
mineral density (BMD) and pathological fractures which lead to significant morbidity. It is …

High-resolution peripheral computed tomography (HR-pQCT) was developed to image bone
microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in …

Osteoporosis is the most common metabolic bone disease in the USA and the world. It is a
subclinical condition until complicated by fracture (s). These fractures place an enormous …

Background Although areal bone mineral density (aBMD) assessed by dual-energy x-ray
absorptiometry (DXA) is the clinical standard for determining fracture risk, most older adults …

Older adults with type 2 diabetes (T2D) tend to have normal or greater areal bone mineral
density (aBMD), as measured by DXA, than those who do not have diabetes (nonT2D). Yet …

There is growing recognition of the role of micro-architecture in osteoporotic bone loss and
fragility. This trend has been driven by advances in imaging technology, which have …

Bone structure is an integral determinant of bone strength. The availability of high resolution
peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure …

The second generation HR-pQCT scanner (XtremeCTII, Scanco Medical) can assess human
bone microarchitecture of peripheral limbs with a 61 μm nominal isotropic voxel size. This is …

Several crosssectional studies have shown that impairment of bone microarchitecture
contributes to skeletal fragility. The aim of this study was to prospectively investigate the …

Osteoporosis, a disease characterized by loss of bone mass and structural deterioration, is
currently diagnosed by dual-energy x-ray absorptiometry (DXA). However, DXA does not …