Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

RNA interference (RNAi), also known as gene silencing, is a biological process that
prevents gene expression in certain diseases such as cancer. It can be used to improve the …

ABSTRACT Introduction Antisense oligonucleotides (ASOs) have emerged as a promising
novel drug modality that aims to address unmet medical needs. A record of six ASO drugs …

Next-generation sequencing technologies have greatly expanded our understanding of
cancer genetics. Antisense technology is an attractive platform with the potential to translate …

Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to
control cell proliferation or in response to DNA damage. The understanding of apoptosis has …

Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

Recent advances in RNA delivery and target selection provide unprecedented opportunities
for cancer treatment, especially for cancers that are particularly hard to treat with existing …

Fascin is a globular actin cross-linking protein that has a major function in forming parallel
actin bundles in cell protrusions that are key specialisations of the plasma membrane for …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Introduction: Multiple “second generation” gapmer antisense oligonucleotides (ASOs) of
varying chemistries have been evaluated as potential therapeutic agents in the clinic …