Protein aggregation is one of the key challenges in the development of protein
biotherapeutics. It is a critical product quality issue as well as a potential safety concern due …

Dengue viral infection has become an increasing global health concern with over two-fifths
of the world's population at risk of infection. It is the most rapidly spreading vector borne …

Antibody protection against flaviviruses is associated with the development of neutralizing
antibodies against the viral envelope (E) protein. Prior studies with West Nile virus (WNV) …

This book gives pharmaceutical scientists an up-to-date resource on protein aggregation
and its consequences, and available methods to control or slow down the aggregation …

The safety and efficacy of protein pharmaceuticals depend not only on biological activity but
also on purity levels. Impurities may be process related because of limitations in …

Recombinant proteins are gaining enormous importance these days due to their wide
application as biopharmaceutical products and proven safety record. Various recombinant …

Dengue represents a major public health problem of growing global importance. In the
absence of specific dengue therapeutics, strategies for disease control have increasingly …

Traditionally, the four dengue virus serotypes have been associated with fever, rash, and the
more severe forms, haemorrhagic fever and shock syndrome. As our knowledge as well as …

Flaviviruses are enveloped single positive-stranded RNA viruses. The capsid (C), a
structural protein of flavivirus, is dimeric and alpha-helical, with several special structural …

A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue
viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue …