Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …

Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
determines prereceptor metabolism and activation of glucocorticoids within peripheral …

Objectives The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a well-
characterised role in the metabolism and activation of endogenous glucocorticoids (GCs) …

Background Acute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary
inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are …

Abstract 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) is a key enzyme that
catalyzes the intracellular conversion of cortisone to physiologically active cortisol. Although …

Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management
of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions …

Introduction Physiological and biochemical processes in the human body occur in a specific
order and show rhythmic variability. Time dependence characterizes the secretion of cortisol …