BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

The human microbiome contains a vast array of microbes and genes that show greater
complexity than the host's own karyome; the functions of many of these microbes are …

A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …

Obesity, increasing in prevalence globally, is the clinical condition most strongly associated
with lowered testosterone concentrations in men and presents as one of the strongest …

Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a
silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type …

One-third of men with obesity or type 2 diabetes have subnormal free testosterone
concentrations. The lower free testosterone concentrations are observed in obese men at all …

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

Obesity prevalence, particularly in children and young adults, is perilously increasing
worldwide foreseeing serious negative health impacts in the future to come. Obesity is linked …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …